Publications
Publication Highlights
Charting the biosynthetic landscape of hybrid polyketide-nonribosomal peptide-specialized lipids
El Arnouki Belhaji F, De Ruysscher D, Vanreppelen G, Huybrechts L, Alanjary MM, Zdouc MM, de los Santos ELC, Demaerel J, Vaneeckhaute E, Van Goethem O, Gerstmans H, Breynaert E, Van Dijck P, Medema MH, Weir A, Lescrinier E, Masschelein J
Non-model bacteria as platforms for endogenous gene expression in synthetic biology
Poppeliers J, Boon M, De Mey M, Masschelein J, Lavigne R
Polyketide synthase-mediated O-methyloxime formation in the biosynthesis of the oximidine anticancer agents
Vriens E1, De Ruysscher D1, Weir A, Dekimpe S, Steurs G, Shemy A, Persoons L, Santos AR, Williams C, Daelemans D, Crump MP, Voet A, De Borggraeve W, Lescrinier E, Masschelein J
Artificial intelligence for natural product drug discovery
Mullowney MW, Duncan K, ..., Masschelein J, ..., van Westen GJP, Hirsch AKH, Linington RG, Robinson SL, Medema M
The kalimantacin polyketide antibiotics inhibit fatty acid biosynthesis in Staphylococcus aureus by targeting the enoyl-acyl carrier protein binding site of FabI
Fage CD1, Lathouwers T1, Vanmeert M, Gao LJ, Vrancken K, Lammens EM, Weir A, Degroote R, Cuppens H, Kosol S, Simpson TJ, Crump MP, Willis CL, Herdewijn P, Lescrinier E, Lavigne R, Anné J, Masschelein J
A dual transacylation mechanism for polyketide synthase chain release in enacyloxin antibiotic biosynthesis
Masschelein J1, Sydor PK1 et al.
Discovery and biosynthesis of gladiolin: a Burkholderia gladioli antibiotic with promising activity against Mycobacterium tuberculosis.
Song L1, Jenner M1, Masschelein J1 et al.
2026
- L. De Vrieze, J. Aerts and J. Masschelein (2026) Comparative pangenomics unveils distinct host adaptation levels and conserved biosynthetic potential in microbiome Clostridia. Molecular Biology & Evolution, accepted for publication.
- RG. Bulai, M. Parolini, KA. Cummins, S, Purnal, E. Lescrinier, J. Rozenski, J. Masschelein and P. Verwilst (2026) Polarity‑Driven Scaffold Optimization of Diaryl Ether FabV Inhibitors to Enhance Aqueous Solubility. ChemMedChem, accepted for publication.
- F. El Arnouki Belhaji, D. De Ruysscher, G. Vanreppelen, L. Huybrechts, M.M. Alanjary, M.M. Zdouc, E.L.C. de los Santos, J. Demaerel, E. Vaneeckhaute, O. Van Goethem, H. Gerstmans, E. Breynaert, P. Van Dijck, M.H. Medema, A. Weir, E. Lescrinier and J. Masschelein (2025) Charting the biosynthetic landscape of hybrid polyketide-nonribosomal peptide-specialized lipids. JACS Au, 6, 3363-3375.
- J. Dillen, T. Eilers, C.E.M.K. Dricot, M. Van Hee, D. Vandenheuvel, J. Masschelein and S. Lebeer (2026) Modular biosynthesis of microbiome-derived polyketides and nonribosomal peptides: insights and opportunities for Lactobacillaceae. Microbial Cell Factories, 25,140.
- S. De Smedt, D. Wéry, H. Vande Capelle, H. Gerstmans, P. Monsieurs, J. Masschelein, P. Ruelens, M. Fauvart and J. Michiels (2026) Heterologous expression and functional characterization of novel microcin B17 congeners from environmental Pseudomonas isolates. Applied Microbiology and Biotechnology, 110, 45.
- J. Poppeliers, M. Boon, M. De Mey, J. Masschelein and R. Lavigne (2026) Non-model bacteria as platforms for endogenous gene expression in synthetic biology. Nature Reviews Bioengineering, 4, 67–81.
2025
- K. Blin, C. Loureiro, N.L.L. Louwen, J.C. Navarro-Muñoz, H. Gerstmans, S.L. Robinson, A. Rutz, Z.L. Reitz, D.T. Doering, J.J.J. van der Hooft, T. Weber, M.H. Medema and M.M. Zdouc. (2025) Strategies for community-sourced biocuration in bioinformatics: a case study on MIBiG 4.0 Briefings in Bioinformatics, 6, bbaf659.
- A. Quintero-Yanes, K. Petit, H. Rodriguez-Villalobos, H. Vande Capelle, O. De Veirman, H. Gerstmans, J. Masschelein, J. Borrero, P. Hols and P. Gabant. (2025) Multiplexed bacteriocin synthesis to combat and prevent antimicrobial resistance. Communications Biology, 8, 1246.
- L. De Vrieze, M. Biltjes, S. Lukashevich, K. Tsurumi and J. Masschelein. (2025) CAGEcleaner: reducing genomic redundancy in gene cluster mining. Bioinformatics, 41, btaf3733.
- K. Blin, S. Shaw, L. Vader, J. Szenei, Z.L. Reitz, H.E. Augustijn, J.D.D. Cediel-Becerra, V. de Crécy-Lagard, R.A. Koetsier, S.E. Williams, P. Cruz-Morales, S. Wongwas, A.E.S. Luchsinger, F. Biermann, A. Korenskaia, M.M. Zdouc, D. Meijer, B.R. Terlouw, J.J.J. van der Hooft, N. Ziemert, E.J.N. Helfrich, J. Masschelein, C. Corre, M.G. Chevrette, G.P. van Wezel, M.H. Medema and T. Weber. (2025) AntiSMASH 8.0: extended gene cluster detection capabilities and analyses of chemistry, enzymology, and regulation. Nucleic Acids Research, 53, W32-W38.
- R-G. Bulai, S. Heylen, W. Van Eynde, M. Cremonini, F. Van Olmen, R. Wicik, E. Lescrinier, J. Rozenski, A. Voet, J. Masschelein* and P. Verwilst*. (2025) Investigating the structure-activity-relationship of diaryl ether-based paFabV inhibitors: a path to novel antibacterials. European Journal of Medicinal Chemistry, 296, 117782.
- R. Maes1, M. Naser Aldine1, H. Gerstmans, C. Michiels* and J. Masschelein*. (2025) Bioactive specialized metabolites from Staphylococcus: diversity, biosynthesis and biotechnological potential. ChemBioChem, 26, e202500105.
- Invited contribution to the ChemBioTalents 2025/26 Special Collection.
- S. Van Hee1, A.E.S. Luchsinger1, A. Cusumano, J. Masschelein, H. Jacquemyn and B. Lievens. (2025) The plant-beneficial fungus Trichoderma harzianum T22 modulates plant metabolism and negatively affects Nezara viridula. BMC Plant Biology, 25, 615.
- J. Pattyn, M. Geerts Danau, D. De Ruysscher, S. Roden, T. Snoekx, J. Masschelein, J. Vaughan-Hirsch and B. Van de Poel. (2025) An assay for assessing 1-aminocyclopropane-1-carboxylate malonyl (MACC) transferase (AMT) activity and its regulation by ethylene. Plant Science, 353, 112401.
- M. Zdouc, K. Blin, N. Louwen, J. Navarro, C. Loureiro, C. Bader, C. Bailey, L. Barra, T. Booth, K. Bozhüyük, J. Cediel-Becerra, Z. Charlop-Powers, M. Chevrette, YH. Chooi, PM. D'Agostino, T. de Rond, E Del Pup, KR. Duncan, W. Gu, N. Hanif, EJN. Helfrich, M. Jenner, Y. Katsuyama, A. Korenskaia, D. Krug, V. Libis, G. Lund, S. Mantri, KD. Morgan, C. Owen, C-S. Phan, B. Philmus, ZL. Reitz, SL. Robinson, KS. Singh, R. Teufel, Y. Tong, F. Tugizimana, D. Ulanova, JM. Winter, C. Aguilar, DY. Akiyama, S. Al-Salihi, M. Alanjary, F. Alberti, G. Aleti, S. Alharthi, MY. Arias Rojo, A. Arishi, HE. Augustijn, NE. Avalon, J. Avelar-Rivas, K. Axt, H. Barbieri, J. Barbosa, L. Segato, SE. Barrett, M. Baunach, C. Beemelmanns, D. Beqaj, T. Berger, J. Bernaldo-Agüero, SM. Bettenbühl, VA. Bielinski, F. Biermann, RM. Borges, R. Borriss, M. Breitenbach, KM. Bretscher, M. Brigham, L. Buedenbender, BW. Bulcock, C. Cano-Prieto, J. Capela, VJ. Carrion, RS. Carter, R. Castelo-Branco, G. Castro-Falcón, FO. Chagas, E. Charria-Girón, A. Chaudhri, V. Chaudhry, H. Choi, Y. Choi, R. Choupannejad, J. Chromy, MS. Chue Donahey, J. Collemare, JA. Connolly, KE. Creamer, M. Crüsemann, A. Arredondo Cruz, A. Cumsille, J-F. Dallery, LC. Damas-Ramos, T. Damiani, M. de Kruijff, BD. Martín, G. Della Sala, J. Dillen, DT. Doering, SR. Dommaraju, S. Durusu, S. Egbert, M. Ellerhorst, B. Faussurier, A. Fetter, M. Feuermann, DP. Fewer, JF. Foldi, A. Frediansya, EA. Garza, A. Gavriilidou, A. Gentile, J. Gerke, H. Gerstmans, JP. Gomez-Escribano, LA. Gonzalez, NE. Grayson, C. Greco, JEG. Gomez, S. Guerra, SG. Flores, A. Gurevich, K. Gutiéerrez-Garcíia, L. Hart, K. Haslinger, B. He, T. Hebra, JL. Hemmann, H. Hindra, L. Höing, DC. Holland, JE. Holme, T. Horch, P. Hrab, J. Hu, TH. Huynh, J-Y. Hwang, R. Iacovelli, D. Iftime, M. Iorio, S. Jayachandran, E. Jeong, JJ. Jing, JJ. Jung, Y. Kakumu, E. Kalkreuter, KB. Kang, S. Kang, W. Kim, GJ. Kim, H. Kim, HU. Kim, M. Klapper, RA. Koetsier, C. Kollten, ÁT. Kovács, Y. Kriukova, N. Kubach, AM. Kunjapur, AK. Kushnareva, A. Kust, J. Lamber, M. Larralde, NJ. Larsen, AP. Launay, N-T-H. Le, S. Lebeer, BTLK. Lee, KL. Lev, S-M. Li, Y-X. Li, C. Licona-Cassani, A. Lien, J. Liu, JAV. Lopez, NV. Machushynets, MI. Macias, T. Mahmud, M. Maleckis, M. Martinez, Y. Mast, MF. Maximo, CM. McBride, RM. McLellan, KM. Bhatt, C. Melkonian, A. Merrild, M. Metsä-Ketelä, DA. Mitchell, AV. Müller, G-S. Nguyen, HT. Nguyen, THJ. Niedermeyer, JH. O'Hare, A. Ossowicki, BO. Ostash, H. Otani, L. Padva, S. Paliyal, X. Pan, M. Panghal, DS. Parade, J. Park, J. Parra, MP. Rubio, HT. Pham, SJ. Pidot, J. Piel, B. Pourmohsenin, M. Rakhmanov, S. Ramesh, MH. Rasmussen, A. Rego, R. Reher, AJ. Rice, A. Rigolet, A. Romero-Otero, LR. Rosas-Becerra, PY. Rosiles, A. Rutz, B. Ryu, LA. Sahadeo, M. Saldanha, L. Salvi, E. Sánchez-Carvajal, C. Santos-Medellin, N. Sbaraini, SM. Schoellhorn, C. Schumm, L. Sehna, N. Selem, AD. Shah, TK. Shishido, S. Sieber, V. Silviani, G. Singh, H. Singh, N. Sokolova, EC. Sonnenschein, M. Sosio, ST. Sowa, K. Steffen, E. Stegmann, AB. Streiff, A. Strüder, F. Surup, T. Svenningsen, DA. Sweeney, J. Szenei, A. Tagirdzhanov, B. Tan, MJ. Tarnowski, BR. Terlouw, R. Thomas, NU. Thome, LRT Ortega, T. Tørring, M. Trindade, A. Truman, M. Tvilum, DW. Udwary, C. Ulbricht, L. Vader, GP. van Wezel, M. Walmsley, R. Warnasinghe, HG. Weddeling, ANM. Weir, K. Williams, SE. Williams, TE. Witte, SM. Wood, K. Yamada, D. Yang, D. Yang, J. Yu, Z. Zhou, N. Ziemert, L. Zimmer, A. Zimmermann, C. Zimmermann, JJJ. van der Hooft, RG. Linington, T. Weber and MH. Medema. (2025) MIBiG 4.0: Advancing Biosynthetic Gene Cluster Curation through Global Collaboration. Nucleic Acids Research, 53, D678-D690.
2024
- L. Van den Berghe, J. Masschelein* and V. Pinheiro*. (2024) From competition to cure: the development of live biotherapeutic products for anticancer therapy in the iGEM competition. Frontiers in Bioengineering and Biotechnology, 12, 1447176.
- Invited contribution by Luka Van den Berghe in recognition of her role as the 2022 KU Leuven iGEM Team Leader
- H. Put1, H. Gerstmans1, H. Vande Capelle1, M. Fauvart*, J. Michiels* and J. Masschelein*. (2024) Bacillus subtilis as a host for natural product discovery and engineering of biosynthetic gene clusters. Natural Product Reports, 41, 1113-1151.
- J. Čivić, N.R. McFarlane, J. Masschelein and J.N. Harvey. (2024) Exploring the selectivity of cytochrome P450 for enhanced novel anticancer agent synthesis. Faraday Discussions, 252, 69-88
- C. Cautereels, J. Smets, P. Bircham, D. De Ruysscher, A. Zimmerman, P. De Rijk, J. Steensels, A. Gorkovskiy, J. Masschelein and K. Verstrepen. (2024) Combinatorial optimization of gene expression through recombinase-mediated promoter and terminator shuffling in yeast. Nature Communications, 15, 1112.
2023
- M.W. Mullowney, K. Duncan, S. Elsayed, N. Garg, N. Martin, D. Meijer, B. Terlouw, F. Biermann, K. Blin, J. Durairaj, M. Gorostiola González, E.J.N Helfrich, F. Huber, S. Leopold-Messer, K. Rajan, T. de Rond, J.A. van Santen, M. Sorokina, M. Balunas, J. van der Hooft, M.A. Beniddir, D. van Bergeijk, L.M. Carroll, C.M. Clark, D.-A. Clevert, C.A. Dejong, C. Du, S. Ferrinho, F. Grisoni, A. Hofstetter, W. Jespers, P. Schwaller, O.V. Kalinina, S.A. Kautsar, H. W. Kim, T.F. Leao, J. Masschelein, E.R. Rees, D. Reker, R. Reher, M. Segler, M. Skinnider, A.S. Walker, B. E. Willighagen, Zdrazil, N. Ziemert, R. Goss, P. Guyomard, A. Volkamer, W.H. Gerwick, H.U. Kim, R. Muller, G. van Wezel, G. Van Westen, A. Hirsch, R. Linington, S.L. Robinson and M. Medema. (2023) Artificial Intelligence For Natural Product Drug Discovery. Nature Reviews Drug Discovery, 22, 895–916.
- E. Vriens1, D. De Ruysscher1, A. Weir, S. Dekimpe, G. Steurs, A. Shemy, L. Persoons, A.R. Santos, C. Williams, D. Daelemans, M.P. Crump, A. Voet, W. De Borggraeve, E. Lescrinier and J. Masschelein. (2023) Polyketide synthase-mediated O-methyloxime formation in the biosynthesis of the oximidine anticancer agents. Angewandte Chemie Int. Ed., 62, e202304476.
- Highlighted as a "Very important paper" by the journal.
- Highlighted in "Hot off the press" Nat. Prod. Rep., 2023, 40, 1590.
- Featured in 'The Brussels Times', 'Het Nieuwsblad', 'Le Soir', 'La Libre', 'Knack' and 'ROB-tv'

2021
- S. Dekimpe and J. Masschelein. (2021) Beyond peptide bond formation: the versatile role of condensation domains in natural product biosynthesis. Natural Product Reports, 38, 1910-1937.
2020
- C.D. Fage1, T. Lathouwers1, M. Vanmeert, L.-J. Gao, K. Vrancken, E.-M. Lammens, A. Weir, R. Degroote, H. Cuppens, S. Kosol, T.J. Simpson, M.P. Crump, C.L. Willis, P. Herdewijn, E. Lescrinier, R. Lavigne, J. Anné and J. Masschelein. (2020) The kalimantacin polyketide antibiotics inhibit fatty acid biosynthesis in Staphylococcus aureus by targeting the enoyl-acyl carrier protein binding site of FabI. Angewandte Chemie Int. Ed, 59, 10549-10556.
- I.T. Nakou, M. Jenner, Y. Dashti, I. Romero-Canelon, J. Masschelein, E. Mahenthiralingam, G.L. Challis. (2020) Genomics-driven discovery of a novel glutarimide antibiotic from Burkholderia gladioli reveals an unusual polyketide synthase chain release mechanism. Angewandte Chemie Int. Ed, 59, 5923145-23153.
- J.A. Davies, F.M. Bull, P.D. Walker, A.N.M. Weir, R. Lavigne, J. Masschelein, T.J. Simpson, P.R. Race, M.P. Crump, C.L. Willis. (2020) Total Synthesis of Kalimantacin A. Organic Letters, 22, 6349-6353.
2019
- J. Masschelein1, P.K. Sydor1, C. Hobson, R. Howe, C. Jones, D.M. Roberts, Z.L. Yap, E. Mahenthiralingam and G.L. Challis. (2019) A dual transacylation mechanism for polyketide synthase chain release in enacyloxin antibiotic biosynthesis. Nature Chemistry, 11, 906-912.
- Highlighted in “Hot off the press” Natural Product Reports, 2019, 36, 1614 and Synfacts, 2020, 16, 0225.
- S. Kosol1, A. Gallo1, D. Griffiths1, T.R. Valentic, J. Masschelein, M. Jenner, E.D.L. Santos, L. Manzi, D. Rea, V. Fülop, N.J. Oldham, S.-C. Tsai, G.L. Challis and J.R. Lewandowski. (2019) Structural basis for chain release from the enacyloxin polyketide synthase. Nature Chemistry, 11, 913-923.
- S. Zhou, L. Song, J. Masschelein, F.A.M. Sumang, I.A. Papa, T.O. Zulaybar, A.B. Custodio, D. Zabala, E.P. Alcantara, E.L.C. de los Santos and G.L. Challis. (2019) Pentamycin biosynthesis in Philippine Streptomyces sp. S816: Cytochrome P450-catalysed installation of the C-14 hydroxyl group. ACS Chemical Biology, 14, 1305-1309.
- Highlighted in “Hot off the press” Natural Product Reports, 2019, 36, 1039.
- M. Jenner, X. Jian, Y. Dashti, J. Masschelein, C. Hobson, D.M. Roberts, C. Jones, S. Harris, J. Parkhill, H. A. Raja, N.H. Oberlies, C.J. Pearce, E. Mahenthiralingam and G.L. Challis. (2019) An unusual Burkholderia gladioli double chain-initiating nonribosomal peptide synthetase assembles ‘fungal’ icosalide antibiotics. Chemical Science, 10, 5489-5494.
2018
- G.L. Challis, X. Jian, C. Hobson , J. Masschelein. (2018) Novel Enacyloxin Derivatives. PCT Int. Appl., WO/2018/193273.
2017
- G.L. Challis, D.J. Griffiths, J. Masschelein. (2017) Antimicrobial Agents. PCT Int. Appl., WO/2017/182828.
- I.R.G. Thistlethwaite, F.M. Bull, C. Cui, P.D. Walker, S.-S. Gao, L. Wang, Z. Song, J. Masschelein, R. Lavigne, M.P. Crump, P.R. Race, T.J. Simpson and C.L. Willis. (2017) Elucidation of the relative and absolute stereochemistry of the kalimantacin/batumin antibiotics. Chemical Science, 8, 6196-6201.
- L. Song1, M. Jenner1, J. Masschelein1, C. Jones, M.J. Bull, S.R. Harris, R.C. Hartkoorn, A. Vocat, I. Romero-Canelon, P. Coupland, G. Webster, M. Dunn, R. Weiser, C. Paisey, S.T. Cole, J. Parkhill, E. Mahenthiralingam and G.L. Challis. (2017) Discovery and biosynthesis of gladiolin: a Burkholderia gladioli antibiotic with promising activity against Mycobacterium tuberculosis. Journal of the American Chemical Society, 139, 7974-7981.
- Featured in the Science and Technology section of The Economist (24 June 2017).

- Highlighted in American Chemical Society (14 June 2017).

- Featured in the Science and Technology section of The Economist (24 June 2017).
- J. Masschelein1, M. Jenner1 and G.L. Challis. (2017) Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights. Natural Product Reports, 34, 712-783.
Featured on the front cover.

- U.R. Awodi1, J.L. Ronan1, J. Masschelein1, E.L.C. de los Santos and G.L. Challis. (2017) Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis. Chemical Science, 8, 411-415.
2016
- B. Uytterhoeven, K. Appermans, L. Song, J. Masschelein, T. Lathouwers, C.W. Michiels and R. Lavigne. (2016) Systematic analysis of the kalimantacin assembly line NRPS module using an adapted targeted mutagenesis approach. MicrobiologyOpen, 5, 279-286.
2015
- M. Medema, R. Kottmann, P. Yilmaz, M. Cummings, J. Biggins, K. Blin, I. de Bruijn, Y. Chooi, J. Claesen, R. Coates, P. Cruz-Morales, S. Duddela, S. Düsterhus, D. Edwards, D. Fewer, N. Garg, C. Geiger, J. Gomez-Escribano, A. Greule, M. Hadjithomas, A. Haines, E. Helfrich, M. Hillwig, K. Ishida, A. Jones, C. Jones, K. Jungmann, C. Kegler, H. Kim, P. Kötter, D. Krug, J. Masschelein, A. Melnik, S. Mantovani, E. Monroe, M. Moore, N. Moss, H. Nützmann, G. Pan, A. Pati, D. Petras, F. Reen, F. Rosconi, Z. Rui, Z. Tian, N. Tobias, Y. Tsunematsu, P. Wiemann, E. Wyckoff, X. Yan, G. Yim, F. Yu, Y. Xie, B. Aigle, A. Apel, C. Balibar, E. Balskus, F. Barona-Gómez, A. Bechthold, H. Bode, R. Borriss, S. Brady, A. Brakhage, P. Caffrey, Y. Cheng, J. Clardy, R. Cox, R. DeMot, S. Donadio, M. Donia, W. van der Donk, P. Dorrestein, S. Doyle, A. Driessen, M. Ehling-Schulz, K. Entian, M. Fischbach, L. Gerwick, W. Gerwick, H. Gross, B. Gust, C. Hertweck, M. Höfte, S. Jensen, J. Ju, L. Katz, L. Kaysser, J. Klassen, N. Keller, J. Kormanec, O. Kuipers, T. Kuzuyama, N. Kyrpides, H. Kwon, S. Lautru, R. Lavigne, C. Lee, B. Linquan, X. Liu, W. Liu, A. Luzhetskyy, T. Mahmud, Y. Mast, C. Méndez, M. Metsä-Ketelä, J. Micklefield, D. Mitchell, B. Moore, L. Moreira, R. Müller, B. Neilan, M. Nett, J. Nielsen, F. O'Gara, H. Oikawa, A. Osbourn, M. Osburne, B. Ostash, S. Payne, J. Pernodet, M. Petricek, J. Piel, O. Ploux, J. Raaijmakers, J. Salas, E. Schmitt, B. Scott, R. Seipke, B. Shen, D. Sherman, K. Sivonen, M. Smanski, M. Sosio, E. Stegmann, R. Süssmuth, K. Tahlan, C. Thomas, Y. Tang, A. Truman, M. Viaud, J. Walton, C. Walsh, T. Weber, G. van Wezel, B. Wilkinson, J. Willey, W. Wohlleben, G. Wright, N. Ziemert, C. Zhang, S. Zotchev, R. Breitling, E. Takano, F. Glöckner. (2015) Minimum information about a biosynthetic gene cluster. Nature Chemical Biology, 11, 625-631.
- J. Masschelein, C. Clauwers, K. Stalmans, Y. Briers, A. Aertsen, C. Michiels and R. Lavigne. (2015) The zeamine antibiotics affect the integrity of bacterial membranes. Applied and Environmental Microbiology, 81, 1139-1146.
- J. Masschelein, C. Clauwers, U.R. Awodi, K. Stalmans, W. Vermaelen, E. Lescrinier, A. Aertsen, C. Michiels, G.L. Challis and R. Lavigne. (2015) A combination of polyunsaturated fatty acid, nonribosomal peptide and polyketide biosynthetic machinery is used to assemble the zeamine antibiotics. Chemical Science, 6, 923-929.
2014
- R. Van Houdt, D. Van der Lelie, J. Izquierdo, A. Aertsen, J. Masschelein, R. Lavigne, C. Michiels and S. Taghavi. (2014) Genome sequence of Serratia plymuthica RVH1, isolated from a raw vegetable processing line. Genome Announcements, 2, e00021-14.
2013
- A. Haines, Z. Song, R. Farmer, C. Williams, J. Hothersall, E. Ploskon, P. Wattana-Amorn, E. Stephens, E. Yamada, R. Gurney, Y. Takebayashi, J. Masschelein, R. Cox, R. Lavigne, C. Willis, T. Simpson, J. Crosby, P. Winn, C. Thomas, M. Crump. (2013) A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesis. Nature Chemical Biology, 9, 685-692.
- J. Masschelein, W. Mattheus, L.-J. Gao, P. Moons, R. Van Houdt, B. Uytterhoeven, C. Lamberigts, E. Lescrinier, J. Rozenski, P. Herdewijn, A. Aertsen, C. Michiels and R. Lavigne. (2013) A PKS/NRPS/FAS hybrid gene cluster from Serratia plymuthica RVH1 encoding the biosynthesis of three broad spectrum, zeamine-related antibiotics. PloS One, 8, e54143.
2010
- W. Mattheus, J. Masschelein, L.-J. Gao, P. Herdewijn, B. Landuyt, G. Volckaert and R. Lavigne. (2010) The kalimantacin/batumin biosynthesis operon encodes a self-resistance isoform of the FabI bacterial target. Chemistry & Biology, 17, 1067-1071.
- W. Mattheus, L.-J. Gao, P. Herdewijn, B. Landuyt, J. Verhaegen, J. Masschelein, G. Volckaert and R. Lavigne. (2010) Isolation and purification of a new kalimantacin/batumin-related polyketide antibiotic and elucidation of its biosynthesis gene cluster. Chemistry & Biology, 17, 17, 149-159.