Publications

Publication Highlights

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JACS Au

Charting the biosynthetic landscape of hybrid polyketide-nonribosomal peptide-specialized lipids

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El Arnouki Belhaji F, De Ruysscher D, Vanreppelen G, Huybrechts L, Alanjary MM, Zdouc MM, de los Santos ELC, Demaerel J, Vaneeckhaute E, Van Goethem O, Gerstmans H, Breynaert E, Van Dijck P, Medema MH, Weir A, Lescrinier E, Masschelein J

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nat rev bio

Non-model bacteria as platforms for endogenous gene expression in synthetic biology

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Poppeliers J, Boon M, De Mey M, Masschelein J, Lavigne R

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Angew

Polyketide synthase-mediated O-methyloxime formation in the biosynthesis of the oximidine anticancer agents

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Vriens E1, De Ruysscher D1, Weir A, Dekimpe S, Steurs G, Shemy A, Persoons L, Santos AR, Williams C, Daelemans D, Crump MP, Voet A, De Borggraeve W, Lescrinier E, Masschelein J

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nat rev dd

Artificial intelligence for natural product drug discovery

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Mullowney MW, Duncan K, ..., Masschelein J, ..., van Westen GJP, Hirsch AKH, Linington RG, Robinson SL, Medema M

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Angew

The kalimantacin polyketide antibiotics inhibit fatty acid biosynthesis in Staphylococcus aureus by targeting the enoyl-acyl carrier protein binding site of FabI

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Fage CD1, Lathouwers T1, Vanmeert M,  Gao LJ, Vrancken K, Lammens EM, Weir A, Degroote R, Cuppens H, Kosol S, Simpson TJ, Crump MP, Willis CL, Herdewijn P, Lescrinier E, Lavigne R, Anné J, Masschelein J

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Nat Chem

A dual transacylation mechanism for polyketide synthase chain release in enacyloxin antibiotic biosynthesis

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Masschelein J1, Sydor PK1 et al.

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JACS

Discovery and biosynthesis of gladiolin: a Burkholderia gladioli antibiotic with promising activity against Mycobacterium tuberculosis.

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Song L1, Jenner M1, Masschelein J1 et al.